According to our computer model, the San Francisco 49ers will beat the Arizona Cardinals when they square off at Levi's Stadium on Sunday, October 1 (at 4:25 PM ET). We have a complete breakdown, regarding the point spread, total and final score, available in this article.

The 49ers have been a difficult matchup for opposing teams, as they rank top-five in both total offense (fourth-best with 399 yards per game) and total defense (third-best with 258.3 yards allowed per game) this season. With 329.7 total yards per game on offense, the Cardinals rank 18th in the NFL in 2023. Defensively, they rank 26th, allowing 367.7 total yards per contest.

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Cardinals vs. 49ers Predictions and Picks

ATS Over/Under Score Prediction
Cardinals (+14.5) Over (44) 49ers 29, Cardinals 16

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Cardinals Betting Info

  • Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 12.5% chance to win.
  • Arizona has put together a 3-0-0 record against the spread this season.
  • Arizona games have gone over the point total twice this season.
  • Cardinals games average 40.2 total points, 3.8 fewer than the total for this matchup.

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49ers Betting Info

  • The implied moneyline probability for this matchup gives the 49ers a 91.7% chance to win.
  • San Francisco has a record of 2-0-1 against the spread this season.
  • So far this season, one San Francisco game has hit the over.
  • 49ers games this season have posted an average total of 43.5, which is 0.5 points fewer than the total for this matchup.

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Cardinals vs. 49ers 2023 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
San Francisco 30 14 30 12 30 15
Arizona 24 22.3 28 23.5 16 20

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