According to the Tempe Fire Medical Rescue Department, the two kids and one of the adults were taken to the hospital, all of them in serious but stable condition. An agency spokesman said their injuries were not life-threatening.
The fourth patient was treated for minor injuries. The fifth refused transport.
The Tempe Police Department tweeted that northbound Priest Drive was closed at Alameda Drive.
Aerial video from the Penguin Air & Plumbing News Chopper showed a badly damaged SUV in the middle of the intersections and a blue car in one of the crosswalks, its front tires almost on the sidewalk corner.
Investigators are working to piece together the moments leading up to the crash, but at this point, no other information is available.