The airline announced Tuesday that the service would be seasonal, starting Nov. 8 and running through April 24.
"Spirit Airlines' expansion to O'Hare is more proof that Phoenix-Mesa Gateway Airport is now a major commercial airport," said Phoenix-Mesa Airport Gateway Board Chairman and Mesa Mayor Scott Smith in a news release. "Mesa and the entire valley is 'Chicago West' in many ways and we are looking forward to people flying Spirit Airlines between both regions, especially during the holidays and spring training."
The announcement comes less than a week after the city of Mesa broke ground on a $99 million spring training complex for the Chicago Cubs.
Spirit Airlines senior sales director Michael Pewther tells the Arizona Republic that the training complex was on a major reason for additional service.
The facility is expected to be completed in time for the 2014 spring training season.