Cardinals QB leaves game with head injury

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Arizona Cardinals' Kevin Kolb walks off the field after being knocked to the ground by San Francisco 49ers' Justin Smith during the first quarter in an NFL football game, Sunday, Dec. 11, 2011, in Glendale, Ariz.(AP Photo/Paul Connors) By Paul Connors Arizona Cardinals' Kevin Kolb walks off the field after being knocked to the ground by San Francisco 49ers' Justin Smith during the first quarter in an NFL football game, Sunday, Dec. 11, 2011, in Glendale, Ariz.(AP Photo/Paul Connors) By Paul Connors

GLENDALE, Ariz. (AP) -- Arizona quarterback Kevin Kolb left Sunday’s game against San Francisco after the first series following a blow to the head.

Kolb was hurt when he was hit as he tried to throw on a third-down play. He fumbled, but the Cardinals recovered. He was replaced by John Skelton, who threw three interceptions and was benched after three quarters in Arizona’s 23-7 loss at San Francisco on Nov. 20.

Kolb was making his second start after missing four games with a right turf toe and bruise to the side of the same foot. The team announced early in the third quarter that Kolb would not return.