Bills lose Edwards, first game of season to Cards

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GLENDALE, Ariz. (AP) -- The Buffalo Bills lost their quarterback and, emphatically, their first game of the season.

Rookie Tim Hightower had a pair of touchdown runs and Kurt Warner threw to Larry Fitzgerald twice for scores to lead the Arizona Cardinals to a 41-17 victory over the Bills on Sunday.

Second-year quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from Cardinals safety Adrian Wilson on the third play of the game. It was the Bills' defense that collapsed after that.